Spray Drying of Biologics

Serán supports both formulation development and particle design of biologics for improved stability and to enable alternative routes of delivery. From protein therapeutics to lipid nanoparticles carrying RNA, Serán specializes in comprehensive design of solid-state formulations for optimal long-term stability while considering the unique requirements of each target product profile. Spray dried formulations are enabling for advanced products such as high concentration protein suspensions, pulmonary delivery of peptides, proteins, and nucleic acids, and targeted oral delivery.

Serán is experienced in working with a wide variety of biologic modalities including peptides, proteins, phages, and nucleic acids. Solid state formulations for these biologic modalities have the potential to significantly improve product stability and to enable integration into advanced drug delivery systems. The application of spray drying enables a free-flowing powder and the ability to engineer particle properties. The ability to intentionally design these particles is critical for downstream incorporation and performance in drug delivery systems, including inhalable powders, injectable suspensions, or long-acting implants.